Cisco Firepower 4100 Series appliances The Cisco Firepower 4100 Series is a family of seven threat-focused NGFW security platforms. Their throughput range addresses data center and internet edge use cases. They deliver superior threat defense, at faster speeds, with a smaller footprint. Cisco Firepower 4100 Series supports flow-offloading, programmatic orchestration, and the management of security services with RESTful APIs. Network Equipment Building Standards (NEBS)-compliance is supported by the Cisco Firepower 4120 platform. The 4100 Series platforms can run either the Cisco ASA Firewall or Cisco Firepower Threat Defense (FTD) software.